• Nasal Spray

MOTS-C Nasal Spray

$225.00

MOTS-C is a small peptide that comes from mitochondrial DNA, which is the DNA inside your cells’ energy-producing structures. In research studies, MOTS-c acts like a signalling molecule that helps cells adjust their metabolism, respond to stress, and manage energy. 

Scientists have mainly studied MOTS-c in animals and in some early human research to understand how it might influence things like: 

  • Metabolism: In studies, MOTS-C appears to modulate cellular responses to glucose, affecting fuel demand and energy balance, especially during stress or low-energy conditions.
  • Exercise-Related Processes: Some studies call MOTS-C an “exercise mimetic” because it activates many of the same energy pathways that turn on during physical activity, which is linked to endurance, energy use, and stress adaptation.
  • How Cells Handle Stress as They Age: MOTS-C may help the body cope with stress and have a role in protecting cells from oxidative stress. 

Our 10 mL MOTS-C peptide nasal spray contains 20 mg total peptide, releasing a precise 250 mcg amount for lab research. Each bottle contains 80 sprays.

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⚠️ Notice: This product is for research use only and intended solely for laboratory testing. It is not for human or animal use. Only qualified professionals should handle it. This product is not a drug, food, or cosmetic.
mots-c dna molecular structure

What is MOTS-C?

MOTS-C is short for Mitochondrial ORF of the Twelve S rRNA-coding gene- C. It’s a small peptide produced from mitochondrial DNA rather than nuclear DNA. Its primary function is as a signalling molecule, communicating metabolic information to various tissues. 

Early research shows that MOTS-C can move from mitochondria to the cytoplasm and nucleus, where it influences pathways involved in energy regulation, stress response, and metabolic balance. Because of this, it’s an intriguing compound for research involving metabolic health, aging, exercise adaptation, and inflammation.

MOTS-C Chemical Information

Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Molecular formula: C101H152N28O22S2
Molecular weight: ~2174.6 g/mol
Form: Synthetic peptide, nasal spray
Other Ingredients: Lab-Grade Distilled Water.

Each batch of MOTS-C peptide undergoes in-house and third-party lab analysis to confirm:

  • Identify (peptide sequencing verification)
  • Purity (≥99% by HPLC)
  • Absence of contaminants (microbial, heavy metals, solvents)

Lab testing ensures that the material provided is consistent, high-quality, and suitable for research purposes.

Research Related to MOTS-C

Here are some highlighted studies related to the MOTS-C research peptide. While these studies are promising, MOTS-C isn’t approved as a drug or dietary supplement, which means its use remains limited to research. 

Metabolic Regulation & Insulin Signaling

Studies show that MOTS-C interacts with pathways involved in muscle glucose uptake, AMPK activation, and mitochondrial stress response. In studies on high-fat-fed and aged mice, MOTS-C helped with insulin sensitivity [1]. 

Fat Metabolism & Body Composition

Cold-exposure studies show that MOTS-C promotes the “browning” of white fat and improves cold tolerance, suggesting higher energy expenditure through thermogenesis. Reviews of studies similar to this indicate that MOTS-C could eventually help manage obesity and age-related metabolic decline, though no human trials have been started yet [2, 3]

Exercise-Mimetic Effects

MOTS-C is nicknamed the “exercise-like” peptide because some studies show it activates metabolic pathways associated with endurance and adaptive energy use. Research in mice demonstrates improved exercise capacity and stress resilience after MOTS-C administration [4].  

Sources

  1. Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., … & Cohen, P. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell metabolism, 21(3), 443-454.
  2. Zheng, Y., Wei, Z., & Wang, T. (2023). MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 14, 1120533.
  3. Lu, H., Tang, S., Xue, C., Liu, Y., Wang, J., Zhang, W., … & Chen, J. (2019). Mitochondrial-derived peptide MOTS-c increases adipose thermogenic activation to promote cold adaptation. International journal of molecular sciences, 20(10), 2456.
  4. Reynolds, J. C., Lai, R. W., Woodhead, J. S., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., … & Lee, C. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature communications, 12(1), 470.

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What does “For Research Use Only” mean?

All products on Stemcode are intended strictly for laboratory, academic, and scientific research purposes. They are not approved for human or veterinary use.

Due to the sensitive nature of research materials used, all sales are final unless the product arrives damaged or incorrect.

No. Resale or repackaging without authorization is prohibited. Our products are solely for research.

At this moment, we ship only within the United States.

Each product page includes specific storage guidelines (e.g., refrigeration or room temperature).

Description

MOTS-C is a small peptide that comes from mitochondrial DNA, which is the DNA inside your cells’ energy-producing structures. In research studies, MOTS-c acts like a signalling molecule that helps cells adjust their metabolism, respond to stress, and manage energy. 

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