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Documented in Peer-Reviewed Research

GHK-Cu

Copper Peptide Complex

GHK-Cu is a naturally occurring tripeptide-copper complex with documented effects on gene expression, collagen synthesis, and extracellular matrix remodeling in published literature.

  • Collagen I & III Synthesis
  • ECM Remodeling
  • Anti-Inflammatory
  • Gene Expression Modulation

Quantified findings reported in the literature

4,000+

human genes modulated by GHK-Cu in gene expression analysis

Pickart & Margolina, IJMS 2018

70%

increase in collagen synthesis observed in fibroblast cultures treated with GHK-Cu

Pickart et al., BioMed Res Int 2015

47%

reduction in TNF-alpha inflammatory markers in GHK-Cu treated tissue models

Pickart & Margolina, IJMS 2018

96-99%

HPLC-verified purity range across published Certificates of Analysis

Stemcode Peptides COA data

32

collagen and ECM-related genes upregulated by GHK-Cu in connectivity map data

Pickart et al., BioMed Res Int 2015

Published, peer-reviewed studies

  1. Int J Mol Sci2018

    Regenerative and protective actions of the GHK-Cu peptide in the light of new gene data

    Review of GHK-Cu gene expression data showing modulation of 4,000+ human genes involved in tissue remodeling, antioxidant defense, and anti-inflammatory pathways.

    View source on PubMed/DOI ↗
  2. BioMed Res Int2015

    GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration

    Comprehensive analysis of GHK-Cu's role in stimulating collagen synthesis, ECM remodeling, and dermal repair through multiple signaling pathways.

    View source on PubMed/DOI ↗
  3. Cosmetics2012

    GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes

    Study demonstrating GHK-Cu's regulation of antioxidant gene expression and copper-dependent protective mechanisms in skin tissue.

    View source on PubMed/DOI ↗
  4. J Pept Sci2008

    The human tri-peptide GHK and tissue remodeling

    View source on PubMed/DOI ↗

Third-party analytical reports

Certificates of Analysis from independent laboratories for products supplied by Stemcode. Reported values describe the analysed material; they are reported as documented and are distinct from the published literature above.

GHK-CuFreedom Diagnostics
Purity (HPLC)
99.163%
Net content
56.58 mg
Lot
GHV0050MG-2601
COA #
2603200338
Report date
03/23/2026
Endotoxin
Pass
View full report ↗
GHK-CuFreedom Diagnostics
Purity (HPLC)
99.058%
Net content
1.99 mg
Lot
GHT7200MCG-2601
COA #
2604100411
Report date
04/12/2026
View full report ↗
GHK-CuFreedom Diagnostics
Purity (HPLC)
99.876%
Net content
6.86 mg/mL
Lot
SP26-GHN30
COA #
2604100420
Report date
04/12/2026
View full report ↗

Stemcode supplies GHK-Cu as a research-grade compound for laboratory research use only — not for human or animal consumption.

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Every compound is documented in published, peer-reviewed literature. Our research library indexes 43 studies across 35 journals for 20 compounds.

Our Studies →
43

Peer-reviewed studies in our research library have examined the mechanisms of action of these peptide compounds.

20
Peptide Compounds
35
Journals Referenced
43
Published Studies

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