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Nasal Spray

Semax Nasal Spray

$130

Synthetic ACTH(4-10) analog heptapeptide nasal spray, 30mg total, 80 sprays per bottle.

30mg totalTotal
375 mcgPer spray
80Sprays
Semax (ACTH 4-10 Analogue)
Independently tested
Batch SP26-SMN30 tested 07/17/2026 Qalitex
Download COA (PDF)
1
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Complete the research set
Save $26 when purchased together
Neuro set

Semax and Selank are commonly co-studied in cognition and anxiety behavioral models.

Semax Nasal Spray
Semax Nasal SprayThis item
$130
Set total$234$260

For research use only — not for human consumption.

Certificate of Analysis
Net Content 33 mg
Lot # SP26-SMN30

Tested by Qalitex · 07/17/2026

Reference Chemistry

Chemical Specification

CAS #
80714-61-0
Molecular Formula
M.W.
813.93 g/mol

Reference chemistry verified against PubChem. HPLC purity is the most recent reported value from an on-file COA for this product.

RESEARCH USE ONLY — not for human or animal consumption. Not for diagnostic or therapeutic use.

Key Ingredients

Semax (ACTH 4-10 Analogue)

A synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from adrenocorticotropic hormone. Research documents effects on BDNF expression, neuronal survival, and cognitive function in pre-clinical models.

Discover the research
BDNF ExpressionNeuroprotectionCognitive Research
Description

Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied for its nootropic and neuroprotective properties.

Research Background

Semax has been investigated in preclinical models for its effects on brain-derived neurotrophic factor (BDNF) expression, cognitive function, and neuroprotection. Unlike the parent ACTH molecule, Semax does not exhibit steroidogenic activity, making it a selective tool for studying melanocortin-mediated neuroprotection. For research use only.

Semax is also stocked combined 1:1 with Selank as a single Semax and Selank nasal spray (15mg of each per bottle) for programs that study both heptapeptides.

Ingredients & Dosage
Semax 375 mcg per spray

Inactive ingredients / formulation base

Normal Saline (pH 6.0) Base solution
Benzalkonium Chloride (BKC) 0.01% preservative
Lab-Grade Distilled Water QS

Amino Acid Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

SKU: SMN0030MG

Shipping & Storage

Shipping: Every order ships 2-Day — free on orders $150+, $4.99 otherwise. Orders placed before 3 PM PT on a business day dispatch the same day, and delivery is typically 2 business days after dispatch.

Storage: Store in a cool, dry place. Refrigeration recommended after opening for optimal stability. Keep away from direct sunlight.

Regulatory Statement

For laboratory and research use only. Not for human or animal consumption. This product is sold exclusively to qualified researchers and licensed laboratories.

This product is not a drug, food, or cosmetic, and is not for diagnostic or therapeutic use. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

A certificate of analysis (COA) is available for this product — view the published COA.

Where can I buy Semax nasal spray for research?

Semax nasal spray is available to buy directly from Stemcode Peptides for laboratory research use. Orders ship from the United States, and every batch is tested in the United States by an independent third-party lab — the certificate of analysis is published on this page. For research use only; not for human consumption.

Semax Nasal Spray $130
ACTH

Synthetic Heptapeptide

Documented in Peer-Reviewed Research

ACTH(4-10) analogue with neuroprotective research applications

Semax is a synthetic heptapeptide derived from the ACTH(4-7) fragment with a Pro-Gly-Pro C-terminal extension. Developed at the Institute of Molecular Genetics in Moscow, it has been studied for nootropic and neuroprotective properties.

BDNF Expression
Neuroprotection
Cognitive Function
Neuroplasticity

Published Research Data

Quantified findings from peer-reviewed studies on Semax


7

amino acid residues in the Semax heptapeptide sequence

Ashmarin et al., 1995


96-99%

HPLC-verified purity range across published batch testing

Stemcode Peptides COA data

Published Research

Studies on Semax

2006 Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus Brain Res

Study demonstrating Semax-induced upregulation of BDNF and its receptor TrkB in rat hippocampus and cortex, supporting neuroprotective mechanisms.

Brain Res, 2006 View Publication
2005 Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency Zh Nevrol Psikhiatr Im S S Korsakova
Zh Nevrol Psikhiatr Im S S Korsakova, 2005 View Publication
1997 A nootropic adrenocorticotropin analog 4-10-semax (15 years experience in its design and study) Zh Vyssh Nerv Deiat Im I P Pavlova
Zh Vyssh Nerv Deiat Im I P Pavlova, 1997 View Publication
COMPARE TO OTHER

Why Research Peptides

Amino Acids
Single Units
Proteins
Large Chains
Small Molecules
Synthetic
Polypeptides
>50 AA
Defined primary sequence
Varies
Precise molecular weight <10 kDa
Varies
Lyophilization compatible
Varies
Varies
Limited
Receptor binding specificity data
Limited
Varies
Limited
Stable in aqueous reconstitution
Varies
Varies
Sequence customizable for research
Limited
Limited

All comparisons reflect general industry practices. Stemcode products are intended solely for laboratory research and are not for human consumption.

The Research Standard

Generic API
Bulk Supplier
Research Blend
Compound Mix
Liquid Solution
Pre-dissolved
Unverified Source
Grey Market
HPLC purity testing with published COAs
Varies
Varies
Independent third-party COA
Varies
Limited
Ready-to-use liquid format
Varies
Varies
Varies
Varies
Sequence verified by mass spec
Limited
Limited
Endotoxin / LAL tested
Limited
Limited
Documented sterile filtration
Varies
Varies

All comparisons reflect general industry practices. Stemcode products are intended solely for laboratory research and are not for human consumption.

Frequently Asked Questions

What is Semax nasal spray?

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) and an ACTH(4-10) analogue. It has been investigated in preclinical models for effects on brain-derived neurotrophic factor (BDNF) expression and cognitive function. This product is a 30mg / 10ml intranasal solution intended for laboratory research use only.

What is in Stemcode's Semax nasal spray?

Each bottle contains 30mg of Semax (ACTH 4-10 analogue) in a 10ml intranasal solution. It is third-party lab tested, with results published in its Certificate of Analysis, and made in the USA.

Where can I buy Semax nasal spray?

Semax nasal spray is available to order directly from Stemcode for research use. Every batch is lab tested for purity and ships from within the United States.

How should Semax nasal spray be stored?

As a pre-formulated solution, store the nasal spray refrigerated at 2-8°C (36-46°F) and use it within the timeframe indicated on the product label. Keep it away from heat and direct sunlight.

Is Semax nasal spray for human use?

No. Semax and all Stemcode products are sold strictly for in-vitro laboratory and research use only. They are not for human or animal consumption.

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Every compound is documented in published, peer-reviewed literature. Our research library indexes 43 studies across 35 journals for 20 compounds.

Our Studies →
43

Peer-reviewed studies in our research library have examined the mechanisms of action of these peptide compounds.

20
Peptide Compounds
35
Journals Referenced
43
Published Studies

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