Documented in Peer-Reviewed Research

MOTS-c

Mitochondrial-Derived Peptide

MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene. Discovered by Dr. Changhan Lee at USC, it has been studied for its role in metabolic homeostasis and exercise physiology.

Metabolic Regulation
AMPK Activation
Exercise Physiology
Insulin Sensitivity

Appears in: Compounds studied in metabolic research Compounds appearing in longevity literature

Quantified findings reported in the literature

amino acid residues in the MOTS-c peptide sequence

Lee et al., Cell Metab 2015

96-99%

HPLC-verified purity range across published batch testing

Stemcode Peptides COA data

Published, peer-reviewed studies

Cell Metab2015
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Discovery paper identifying MOTS-c as a mitochondrial-derived peptide that regulates metabolic homeostasis through AMPK pathway activation.
View source on PubMed/DOI ↗
Nat Commun2021
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
View source on PubMed/DOI ↗

Third-party analytical reports

Certificates of Analysis from independent laboratories for products supplied by Stemcode. Reported values describe the analysed material; they are reported as documented and are distinct from the published literature above.

MOTS-CQalitex

Net content: 22 mg
Lot: SP26-MON20
COA #: COA-2026-9149604
Report date: 07/17/2026

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MOTS-CQalitex

Net content: 11 mg
Lot: SP26-MOV10
COA #: COA-2026-9149955
Report date: 08/31/2026

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Stemcode supplies MOTS-c as a research-grade compound for laboratory research use only — not for human or animal consumption.

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